The Pickaxe Aliens first appear in Kevin's Big Score, where Kevin meets them to make a deal with Vulkanus for a Grandpa Max hologram device, but Vulkanus instead double-crossed Kevin and makes him absorb a piece of Taydenite, where he was transformed into a Taydenite monster. The Pickaxe Aliens began gathering pieces of Taydenite from Kevin's back. Ben and Gwen arrive to save Kevin. Gwen fought the Pickaxe Aliens while Ben was fighting Valkanus as Big Chill. They manage to defeat the aliens and Vulkanus, where he was throwing small pieces of Taydenite in the air in joy.
The Pickaxe Aliens reappear in Inferno, where Vulkanus is attempting to increase Earth's temperature by planting a giant bomb inside the Earth's core. While Gwen and Kevin were busy fighting the Pickaxe Aliens, Ben defeated Vulkanus and was able to destroy the bomb before it could explode.
In Con of Rath, when the group were trying to get some pieces of Taydenite to fuel their ship in order to deliver Tiffin, Vulkanus and the Pickaxe Aliens showed up after Gwen remarked that whenever there was Taydenite, Vulkanus would be there. Vulkanus insulted Rath, and then a short fight ensued, but Gwen and Kevin were able to convince Rath to go with them.
They return in Hit 'Em Where They Live, where Vulkanus brings out his biggest army of them to fight Big Chill, who was looking for his mother when she was kidnapped by Zombozo, Charmcaster and Vulkanus. Since Gwen was fighting Zombozo, and Kevin was fighting Charmcaster, Big Chill was alone to fight them. When Big Chill realized there were too many to fight, he becomes Ultimate Big Chill and freezes the aliens and Vulkanus in ice, where Vulkanus surrendered.
The Pickaxe Aliens make their first video game appearance in Ben 10: Alien Force (Video Game), where they are still working for Vulkanus and try to make sure Ben and his team do not steal a water-conditioning system for Gorvan.