Natalie Tennyson is the wife of Frank Tennyson, Ben's aunt, and the mother of Gwen. It is evident that she does not like Verdona, by their facial expressions and reactions towards each other.
Natalie doesn't seem to be particularly too fond of Frank's side of the family, as she complains about them by saying they're not as "formal" as her side of the family. She was also seen to have disagreements with Verdona, making stares at each other at every given opportunity.
In What Are Little Girls Made Of?, Verdona wanted to take Gwen to Anodyne with her but needed her parents confirmation. Natalie said she at least wanted Gwen to take on her side of the family while exchanging dirty looks with Verdona, but would let her go to Anodyne. While Verdona said that she would be coming back now and then to visit the family, Natalie gives a sarcastic response saying, "Oh joy."
Natalie returns in Girl Trouble, Gwen talked to her about Sunny and later Gwen told her about Sunny being an Anodite and she tried to stop Sunny from seeing Antonio.
In It's Not Easy Being Gwen, Natalie asked Gwen to write the rest of the invitations for a family reunion, and invited Ben and Kevin over for dinner.