Ben 10 Ultimate Alien: Cosmic Destruction is a video game that involves Ben traveling to iconic real-world locations in search of the parts to an ancient Galvan artifact called the Potis Altiare to save the Earth from total destruction by an evil To'kustar.
Ben 10 Ultimate Alien: Cosmic Destruction is the new game that introduces the new alien heroes: Water Hazard, Armodrillo, AmpFibian, Terraspin and NRG from the Ben 10: Ultimate Alien television series, allowing players to tunnel or beat through evil alien enemies, unleash water blasts, emit radiation beams, shoot electricity bolts and fire, wind attacks, and more, with a unique experience system which lets them upgrade alien attributes and abilities. The game also provides all-new game enhancements such as Quick Switch, which allows players to switch alien forms faster than ever, and Quick Time Events which creates a cinematic experience that guides players through fierce boss battles and challenging puzzle elements. Players will control Ben and up to 16 alien heroes including Ultimate Big Chill, Ultimate Spidermonkey, Ultimate Echo Echo, Ultimate Swampfire, Ultimate Humungousaur, Four Arms (PS3) and Rath (Xbox 360).
On the PSP, when you reach the cutscene where Ben meets Enoch, at the end where Ben says "Yeah yeah, blah blah blah... It's hero time!" and holds out his hand to the Ultimatrix, sometimes the Omnitrix takes the place of it when it shows.
When battling Evil Way Big, he is much taller than the nearby bridge, but in the cutscenes, he was about a quarter of the height of the bridge.
In one of the cutscenes when Will Harangue is talking about Ben causing trouble in various countries it shows AmpFibian shooting yellow electricity instead of blue.
When Echo Echo splits, he says 'Vide and Conquer' instead of divide and conquer.
Way Big's cosmic ray is shown to be green in this game.
During the cutscene between Devil's Tower and The Great Wall, Evil Way Big and Psyphon are seen watching footage of Ultimate Swampfire fighting R.E.D.s, despite the fact that Ultimate Swampfire was not seen in the Devil's Tower level.
Unlike the previous games, this game only includes aliens that can go Ultimate (except Cannonbolt) and the five aliens from the Andromeda Galaxy.
The Ultimate forms are not unlockable; you can only play as them in certain levels. In the DS version, however, when you build up the meter, the alien turns ultimate for a power blast to do a lot of damage to all the enemies on the screen, or if it's an alien without an ultimate (e.g. Waterhazard, Terraspin, NRG, Armodrillo, and Ampfibian), it will do a power blast instead.