Ben 10 Ultimate Alien: Cosmic Destruction is a video game that involves Ben traveling to iconic real-world locations in search of the parts to an ancient Galvan artifact called the Potis Altiare to save the Earth from total destruction by an evil To'kustar.
Ben 10 Ultimate Alien: Cosmic Destruction is the new game that introduces the new alien heroes: Water Hazard, Armodrillo, AmpFibian, Terraspin and NRG from the Ben 10: Ultimate Alien television series, allowing players to tunnel or beat through evil alien enemies, unleash water blasts, emit radiation beams, shoot electricity bolts and fire, wind attacks, and more, with a unique experience system which lets them upgrade alien attributes and abilities. The game also provides all-new game enhancements such as Quick Switch, which allows players to switch alien forms faster than ever, and Quick Time Events which creates a cinematic experience that guides players through fierce boss battles and challenging puzzle elements. Players will control Ben and up to 16 alien heroes including Ultimate Big Chill, Ultimate Spidermonkey, Ultimate Echo Echo, Ultimate Swampfire, Ultimate Humungousaur, Four Arms (PS3) and Rath (Xbox 360).
When battling Evil Way Big, he is much taller than the nearby bridge, but in the cutscenes, he was about a quarter of the height of the bridge.
Way Big's cosmic ray is shown to be green in this game.
During the cutscene between Devil's Tower and The Great Wall, Evil Way Big and Psyphon are seen watching footage of Ultimate Swampfire fighting R.E.D.s, despite the fact that Ultimate Swampfire was not seen in the Devil's Tower level.
When Humungousaur is fighting Evil Way Big his eyes are white until he falls in the water.
When Terraspin hovers his eyes are white.
In the DS, while choosing an alien form only the center of the ultimatrix dial is opened.
In the Wii, when the player fails to complete the Forever Knights Castle once in the shifting bridges, the second time Ben appears in the checkpoint, the metal lock does not disappear and Ben can get through it easily.
During the special report news sceen, AmpFibian's electricity is shown yellow.
The Ultimate forms are not unlockable; the player can only play as them in certain levels. In the DS version, however, when the player builds up the meter, the alien turns ultimate for a power blast to do a lot of damage to all the enemies on the screen, or if it's an alien without an ultimate, it will do a power blast instead. With a cheat, the player can go ultimate any time.
In the museum, after deafeating the Vreedle Brothers, there's a statue of a Vaxasaurian holding a ring. The same statue can be found on Terradino in Vilgax Attacks.
In a cutscene, Ben mentioned his teleportation to Primus in Primus.