Ben 10,000's Headquarters is Ben 10,000's base of operations.
The first headquarters was located in Omnitrix City, near Mount Rushmore. A large statue of Ben 10,000 was built at the center of this headquarters.
In Ben 10,000, this headquarters was where 10 year old Ben met his future self. It was the center of the episode and featured the fight between the Bens and Vilgax.
Another headquarters was built sometime after the events of Ken 10. It also stores ancient alien artifacts Kai's family collected over the years. (Such as Excalibur). It had a Chronoporter which could teleport people to different times and places.
The new Headquarters was first shown in And Then There Was Ben when the other Good Bens came to recruit Ben 10,000 in the fight.
It was again shown at the beginning of the episode The End of an Era, where it featured Ben's and Kai's fight against Animo.